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Pernicious anemia is a rare disorder in which the body does not absorb enough vitamin B12 from the digestive tract, resulting in an inadequate amount of red blood cells (RBCs) produced. Anemia from an underlying autoimmune digestive disorder. Pernicious anemia is characterized by the presence in the blood of large, immature, nucleated cells that are forerunners of red blood cells. That's because anemia a condition in which there aren't enough healthy red blood cells to carry adequate oxygen to your tissues — can make you feel tired. The diagnosis of pernicious anemia is made by means of microscopic examination of the blood and measurement of vitamin B12 and the products of its breakdown in the blood. Vitamin B12 deficiency can have many causes including PA, malabsorption syndromes, and food cobalmin deficiency. Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract.Pernicious anemia is a condition in which the body does not make enough red blood cells due to a lack of vitamin B12 in the body.

Pernicious anemia is a type of anemia characterized by very large red blood cells. Pernicious anemia (PA) is an autoimmune condition of anemia caused by a deficiency of vitamin B12. Anemia from an underlying autoimmune digestive disorder. The disease was named pernicious anemia because it was fatal before treatment became available, first as liver therapy and, subsequently, as purified vitamin B-12. It usually occurs in people whose bodies have lost the ability to absorb vitamin B12 from food. Pernicious anemia is characterized by the presence in the blood of large, immature, nucleated cells that are forerunners of red blood cells. Anemia can be temporary or long term, and it can range from mild to severe. If you were diagnosed with PA at such a young age, chances are you need the B12 replacement now, at the age of 80, more than ever.

Causes of Pernicious Anemia

There are various factors which give rise to the disease Pernicious Anemia , but here we mentioned some of the common causes:

• Atrophic gastritis.
• Removal of all or part of the stomach.
• Genetics.
• Nutrition.
• Infection.
• Gastrointestinal disease.
• Drugs.
• Metabolic disorders.

Symptoms of Pernicious Anemia

Some of the common sign and symptoms of the disease Pernicious Anemia follows:

• Weak muscles.
• Numbness or tingling in hands and feet.
• Difficulty walking.
• Nausea.
• Decreased appetite.
• Weight loss.
• Irritability.
• Lack of energy or tiring easily.
• Diarrhea.
• Increased heart rate.

Treatment of Pernicious Anemia

Find effective treatment methods of treating Pernicious Anemia :

• Usually, injections of vitamin B12 are sufficient to overcome the deficiency.
• Prevent complications, such as heart or nerve damage.
• Provide ongoing followup to make sure that the treatment is working.
• There is also a preparation of Vitamin B12 that may be given intranasally.
• Therapy for pernicious anemia is administration of vitamin B12 as injections under the skin or into the muscle.